The p53/TP53 gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The TP53 gene is located on chromosome 17p13.1. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].

Alternative names: Tumor protein p53 Li-Fraumeni syndrome; P53, TRP53 Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53

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