CK 8/Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
Alternative Names: CK 8/ Cytokeratin 8 / Keratin 8 CK-8, cytokeratin-8, keratin, type II cytoskeletal 8, keratin-8
|Product Name:||Anti-CK8 Antibody|
|Source #:||Mouse Monoclonal|