ERG is a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The expression is mainly in the nucleus. The protein contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. ERG is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, the differentiation and maturation of megakaryocytic cells. The ERG gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing’s sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names: transcriptional regulator ERG, p55, erg-3

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