HER2

HER2

This Her2/neu/ErbB2 gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Alternative names: C-erbB-2; HER-2; HER-2/neu; MLN 19; NEU; NGL; TKR1

Product Name: Anti-HER2 Antibody
Reference #: CE00004
Clone #: UMAB36
Source #: Mouse Monoclonal
Reactivity: Human
Catalog Number &
Aliquote Size #:
C0004MA01-MA | 0.1 mL
C0004MA05-MA | 0.5 mL

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