Expressed by the MGMT gene, O6-methylguanine DNA methyltransferase repairs DNA by demethylating O6-methylguanine to guanosine. The O6-methylguanine causes errors during DNA replication and transcription by base-pairs to thymine rather than cytidine. MGMT methylation is associated with the loss of its protein expression. MGMT expression is variable in cancer tissues.
Alternative names: O6-alkylguanine DNA alkytransferase, AGT, AGAT
| Product Name: | Anti-MGMT Antibody |
|---|---|
| Reference #: | CE00017 |
| Clone #: | UMAB56 |
| Source #: | Mouse Monoclonal |
| Reactivity: | Human |
| Catalog Number & Aliquote Size #: |
C0017MA10-MA | 1.0 mL |
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