This gene encodes indoleamine 2,3-dioxygenase (IDO) – a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
Alternative names: IDO; IDO-1; INDO
|Product Name:||Anti-IDO1 Antibody|
|Source #:||Mouse Monoclonal|
|Catalog Number &
Aliquote Size #:
|C0061MA01-MA | 0.1 mL
C0061MA05-MA | 0.5 mL
C0061MA10-MA | 1.0 mL
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